Use the pinkey finger and thumb of your right hand for Ctrl and Alt and index finger for Del, and use left hand for F4. Though I must admit that stuff712's second way sounds perfect.
yes, there are two ways.
1: use the pinkey finger and thumb of left hand for Ctr and Alt, use index finger for F4, and use left hand for delete
2. Right hand for Ctr Alt, left hand for Delete, and smash the F-row with your head